Our Technology

OVERVIEW
Realizing the Full Potential of Cancer Surgery

VGT-309 works by binding to cathepsins, a family of proteases that are highly overexpressed in a broad range of solid tumors. By binding tightly to these proteases, VGT-309 provides a sustained molecular signal at the tumor site, generating adequate illumination throughout patients’ surgeries. Additionally, because cathepsins are over-expressed in cancer as compared to normal cells, VGT-309 effectively targets cancer cells while generating minimal signals in healthy tissue.

Easy-To-See, Targeted Tumor Marking
VGT-309 fluorescence is only visible once the agent is “activated” by cathepsin protease activity in tumor tissue. This binding-dependent activity increases the tumor-specific signal provided by VGT-309 while minimizing the possibility of background fluorescence.

The imaging component of VGT-309 is the near infrared (NIR) dye indocyanine green (ICG). ICG is compatible with all commercially available NIR intraoperative imaging systems that support MIS technologies and is the preferred dye to minimize confounding background autofluorescence.

Lung Cancer as First Indication

If the disease is diagnosed early and all tumor tissue is removed, surgery can be curative

MIS / Robotic-Assisted Surgery

Offer many benefits in lung cancer, but limit surgeons’ ability to see tumor tissue

VGT-309 Provides the Missing Piece

Optimal tumor visualization with the potential to improve surgical success

Features

Targets and binds tightly (covalently) to cathepsins, a family of proteases that are highly overexpressed across a broad range of solid tumors

Uses near infrared (NIR) dye indocyanine green (ICG)

Benefits

Ensures retention of molecular signal at the tumor site to provide illumination throughout surgery


Creates minimal signal in normal tissue


Offers potential utility across a wide breadth of tumor types

Compatible with all commercially available NIR intraoperative imaging systems that support minimally invasive and robotic-assisted surgery


Minimizes confounding background autofluorescence